Risk Factors Associations Between a Polymorphism in the Gene Encoding Glycoprotein IIIa and Myocardial Infarction or Coronary Artery Disease

RESULTS Of the 791 pt, 225 had acute (n 5 143) or previous MI, and 276 did not have MI or unstable angina. The PI allele was carried by 33.8% of MI pt versus 26.9% of no-MI control subjects, OR 5 1.39 (95% CI, 0.95 to 2.04, p 5 0.09). Angiographically, 549 pt had severe (.60% coronary stenosis) CAD, and 170 had normal coronary arteries (,10% stenosis). The PI allele was found in 31.0% of CAD pt versus 28.2% of no-CAD control subjects, OR 5 1.14 (CI, 0.78 to 1.67, p 5 0.50). When adjusted for six standard risk factors, ORs were 1.47 (CI, 0.98 to 2.20, p 5 0.062) for MI and 1.20 (CI, 0.80 to 1.81, p 5 0.38) for CAD.